The clinical syndrome of primary tic disorder associated with dystonia: A large clinical series and a review of the literature
Identifieur interne : 001335 ( Main/Exploration ); précédent : 001334; suivant : 001336The clinical syndrome of primary tic disorder associated with dystonia: A large clinical series and a review of the literature
Auteurs : Joana Damásio [Royaume-Uni, Portugal] ; Mark J. Edwards [Royaume-Uni] ; Araceli Alonso-Canovas [Royaume-Uni, Espagne] ; Petra Schwingenschuh [Royaume-Uni, Autriche] ; Georg K Gi [Royaume-Uni, Suisse] ; Kailash P. Bhatia [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Anti-Dyskinesia Agents (therapeutic use), Antiparkinson Agents (therapeutic use), Bontoxilysin, Botulinum Toxins (therapeutic use), Dystonia, Dystonia (complications), Dystonia (drug therapy), Female, Gilles de la Tourette syndrome, Humans, Male, Middle Aged, Nervous system diseases, Tic, Tic Disorders (complications), Tic Disorders (drug therapy), Trihexyphenidyl (therapeutic use), Young Adult, botulinum toxin, dystonia, primary tic disorders.
- MESH :
- chemical , therapeutic use : Anti-Dyskinesia Agents, Antiparkinson Agents, Botulinum Toxins, Trihexyphenidyl.
- complications : Dystonia, Tic Disorders.
- drug therapy : Dystonia, Tic Disorders.
- Adult, Age of Onset, Aged, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Background: The co‐occurrence of tics and dystonia as an idiopathic condition has only rarely been reported. We report a series of patients with tics and persistent dystonia, with the aim of determining the prevalence and clinical characteristics of this syndrome. Methods: Analysis of clinical database of patients with tic disorders. Results: From our database of 224 patients with tics, 20 had co‐occurrence of tics and dystonia as a primary disorder. Six patients had Tourette's syndrome, and 2 had idiopathic chronic motor/phonic tics. Twelve of the 20 had adult onset of tics (9 with motor/phonic tics and 3 with motor tics). Dystonia was focal in 12 patients (cervical most common) and segmental in 8. A sensory geste was present in 8. Mean age of tic onset and dystonia was 28.3 ± 19.7 and 40.5 ± 15.3 years, respectively. Tics preceded dystonia in 12, dystonia preceded tics in 4, and 1 patient had simultaneous onset of tics and dystonia. In 3 patients, symptoms' sequence could not be determined. Only 8 patients required treatment for their tics. Botulinum toxin was the mainstay of dystonia treatment (16 patients), whereas 6 received trihexyphenidyl. Six patients each had depression and obsessive compulsive symptoms, and 5 had attention‐deficit and hyperactivity disorder. Discussion: We have further characterized the syndrome of a primary condition of tics associated with persistent focal/segmental dystonia. Apart from the presence of dystonia, our data suggest that these patients are differentiated from pure tic disorders by a later age of onset, lesser severity of tics, and lower frequency of associated features. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23484
Affiliations:
- Autriche, Espagne, Portugal, Royaume-Uni, Suisse
- Angleterre, Communauté de Madrid, Grand Londres
- Londres, Madrid
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Le document en format XML
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Bhatia</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="679">679</biblScope><biblScope unit="page" to="684">684</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8EA54D3CECF1E205E5022436FF6375BA1F276765</idno><idno type="DOI">10.1002/mds.23484</idno><idno type="ArticleID">MDS23484</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Anti-Dyskinesia Agents (therapeutic use)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Bontoxilysin</term><term>Botulinum Toxins (therapeutic use)</term><term>Dystonia</term><term>Dystonia (complications)</term><term>Dystonia (drug therapy)</term><term>Female</term><term>Gilles de la Tourette syndrome</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Tic</term><term>Tic Disorders (complications)</term><term>Tic Disorders (drug therapy)</term><term>Trihexyphenidyl (therapeutic use)</term><term>Young Adult</term><term>botulinum toxin</term><term>dystonia</term><term>primary tic disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Antiparkinson Agents</term><term>Botulinum Toxins</term><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dystonia</term><term>Tic Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term><term>Tic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bontoxilysin</term><term>Dystonie</term><term>Pathologie du système nerveux</term><term>Syndrome de Gilles de la Tourette</term><term>Tic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: The co‐occurrence of tics and dystonia as an idiopathic condition has only rarely been reported. We report a series of patients with tics and persistent dystonia, with the aim of determining the prevalence and clinical characteristics of this syndrome. Methods: Analysis of clinical database of patients with tic disorders. Results: From our database of 224 patients with tics, 20 had co‐occurrence of tics and dystonia as a primary disorder. Six patients had Tourette's syndrome, and 2 had idiopathic chronic motor/phonic tics. Twelve of the 20 had adult onset of tics (9 with motor/phonic tics and 3 with motor tics). Dystonia was focal in 12 patients (cervical most common) and segmental in 8. A sensory geste was present in 8. Mean age of tic onset and dystonia was 28.3 ± 19.7 and 40.5 ± 15.3 years, respectively. Tics preceded dystonia in 12, dystonia preceded tics in 4, and 1 patient had simultaneous onset of tics and dystonia. In 3 patients, symptoms' sequence could not be determined. Only 8 patients required treatment for their tics. Botulinum toxin was the mainstay of dystonia treatment (16 patients), whereas 6 received trihexyphenidyl. Six patients each had depression and obsessive compulsive symptoms, and 5 had attention‐deficit and hyperactivity disorder. Discussion: We have further characterized the syndrome of a primary condition of tics associated with persistent focal/segmental dystonia. Apart from the presence of dystonia, our data suggest that these patients are differentiated from pure tic disorders by a later age of onset, lesser severity of tics, and lower frequency of associated features. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Espagne</li><li>Portugal</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>Grand Londres</li></region><settlement><li>Londres</li><li>Madrid</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Damasio, Joana" sort="Damasio, Joana" uniqKey="Damasio J" first="Joana" last="Damásio">Joana Damásio</name></region><name sortKey="Alonso Anovas, Araceli" sort="Alonso Anovas, Araceli" uniqKey="Alonso Anovas A" first="Araceli" last="Alonso-Canovas">Araceli Alonso-Canovas</name><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J." last="Edwards">Mark J. Edwards</name><name sortKey="K Gi, Georg" sort="K Gi, Georg" uniqKey="K Gi G" first="Georg" last="K Gi">Georg K Gi</name><name sortKey="Schwingenschuh, Petra" sort="Schwingenschuh, Petra" uniqKey="Schwingenschuh P" first="Petra" last="Schwingenschuh">Petra Schwingenschuh</name></country><country name="Portugal"><noRegion><name sortKey="Damasio, Joana" sort="Damasio, Joana" uniqKey="Damasio J" first="Joana" last="Damásio">Joana Damásio</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Alonso Anovas, Araceli" sort="Alonso Anovas, Araceli" uniqKey="Alonso Anovas A" first="Araceli" last="Alonso-Canovas">Araceli Alonso-Canovas</name></region></country><country name="Autriche"><noRegion><name sortKey="Schwingenschuh, Petra" sort="Schwingenschuh, Petra" uniqKey="Schwingenschuh P" first="Petra" last="Schwingenschuh">Petra Schwingenschuh</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="K Gi, Georg" sort="K Gi, Georg" uniqKey="K Gi G" first="Georg" last="K Gi">Georg K Gi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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